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SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.2
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
8
Vitamin D may influence blood clotting
Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction.
Study highlights vitamin D's impact
We explored the connection between vitamin D levels and coronary thrombus load in patients who experienced ST-elevation myocardial infarction (STEMI). The study included 77 patients where we measured serum vitamin D levels, thrombus degree, and other relevant factors.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
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4
Vitamin D3 had limited effects
The Effect of High-Dose Vitamin D3 on Soluble P-Selectin and hs-CRP Level in Patients With Venous Thromboembolism: A Randomized Clinical Trial.
Direct investigation on blood clotting
We investigated the effects of high-dose vitamin D3 on blood clotting parameters in patients suffering from venous thromboembolism (VTE), specifically looking at levels of P-selectin and high-sensitive C-reactive protein (hs-CRP). The study involved 60 participants who were diagnosed with acute deep vein thrombosis or pulmonary embolism.
These patients were randomly divided into two groups—one receiving a single dose of 300,000 IU of vitamin D3 and the other group serving as a control. Over the course of four weeks, we measured the levels of vitamin D, P-selectin, and hs-CRP to assess any changes resulting from the treatment.
While we noticed a significant decline in both P-selectin and hs-CRP in those who received vitamin D3, the overall reductions were not substantial enough to indicate a major benefit. In comparison, only hs-CRP decreased significantly in the control group. Therefore, we conclude that, based on our findings, high-dose vitamin D3 does not show a strong impact on lowering P-selectin levels or hs-CRP in patients with VTE.
These patients were randomly divided into two groups—one receiving a single dose of 300,000 IU of vitamin D3 and the other group serving as a control. Over the course of four weeks, we measured the levels of vitamin D, P-selectin, and hs-CRP to assess any changes resulting from the treatment.
While we noticed a significant decline in both P-selectin and hs-CRP in those who received vitamin D3, the overall reductions were not substantial enough to indicate a major benefit. In comparison, only hs-CRP decreased significantly in the control group. Therefore, we conclude that, based on our findings, high-dose vitamin D3 does not show a strong impact on lowering P-selectin levels or hs-CRP in patients with VTE.
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9
Vitamin D3 impacts blood clotting
1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
Significant effects seen in study
We explored the effects of vitamin D3 on blood clot formation in mice lacking the klotho protein, which plays a role in regulating vitamin D3 levels. In our analysis, we focused on how klotho deficiency impacts platelet function and calcium signaling, pivotal mechanisms involved in clotting.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Read More
Most Useful Reviews
9.5
Maintains blood quality
All tests are perfect. I started taking it in the first trimester of pregnancy, and I’m now 27 weeks along. I bought 2-3 cans and continue taking it. I experienced some issues like belching but no nausea. The small capsules are easy to swallow. It's essential to store them in the fridge, as heat can make them smell like fish. Omega is known to help maintain normal blood quality, preventing blood clots. Monthly tests show my platelets and erythrocytes are normal. I highly recommend it!
Read More
8.8
Pregnancy support discussed
Following two miscarriages, my midwife suggested Folate and Baby Aspirin for my next pregnancy. As directed, I got my progesterone checked. The baby aspirin is intended to help prevent any blood clots. I find this routine easy and would recommend it to any expecting mothers, especially those with complications like mine.
Read More
7.5
Improves blood circulation
After pregnancy, I had an issue with a blood clot on my leg, so I bought this for better blood circulation. Interestingly, after taking it, the problem seems to have improved.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.2
9
Vitamin D3 impacts blood clotting
1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice.
Significant effects seen in study
We explored the effects of vitamin D3 on blood clot formation in mice lacking the klotho protein, which plays a role in regulating vitamin D3 levels. In our analysis, we focused on how klotho deficiency impacts platelet function and calcium signaling, pivotal mechanisms involved in clotting.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Our findings revealed that klotho-deficient platelets exhibited significantly reduced responses to activation, indicating that they might not form clots effectively. Specifically, we observed that calcium signaling pathways, essential for platelet activation and aggregation, were notably inhibited in these mice. The investigation utilized multiple methods, including measuring calcium levels and evaluating platelet function through various biochemical and cellular techniques.
Interestingly, when klotho-deficient mice were given a low-vitamin D diet, we discovered that their platelet function improved, suggesting a direct link between vitamin D3 levels and platelet activity. The reduced activity was associated with decreased expression of critical signaling proteins involved in calcium entry, which vitamin D3 helps regulate. Overall, our study presents evidence that vitamin D3 deficiency due to klotho absence may hinder proper blood clotting mechanisms.
Read More
9
Vitamin D3 reduces blood clot risk
Renin angiotensin system blockade and activated vitamin D as a means of preventing deep vein thrombosis in renal transplant recipients.
Moderate relevance to vitamin D3
We evaluated the potential of vitamin D3, specifically calcitriol, in combination with other medications to prevent deep vein thrombosis (VTE) in renal transplant recipients (RTR). Focusing on how these treatments might influence the occurrence of blood clots, we followed a group of 769 RTRs over several months post-transplant.
Our findings revealed that 96 of these recipients experienced a first episode of VTE. We noticed a significant difference in rates of blood clots among those who received calcitriol alongside angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs). In fact, recipients on the combination therapy had a markedly lower rate of VTE, showing a promising 60% reduction in risk.
However, it is important to note that the isolated effect of vitamin D3 without other treatments wasn't fully determined in this study. While calcitriol showed favorable outcomes when used with blood pressure medications, further research could help clarify its individual impact on clot prevention. Overall, this research highlights the importance of collaborative strategies in managing thrombotic complications for transplant patients.
Our findings revealed that 96 of these recipients experienced a first episode of VTE. We noticed a significant difference in rates of blood clots among those who received calcitriol alongside angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs). In fact, recipients on the combination therapy had a markedly lower rate of VTE, showing a promising 60% reduction in risk.
However, it is important to note that the isolated effect of vitamin D3 without other treatments wasn't fully determined in this study. While calcitriol showed favorable outcomes when used with blood pressure medications, further research could help clarify its individual impact on clot prevention. Overall, this research highlights the importance of collaborative strategies in managing thrombotic complications for transplant patients.
Read More
9
Eicosapentaenoic acid influences clotting
Emergence of omega-3 fatty acids in biomedical research.
Moderate interest from study findings
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.
Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
Read More
9
EPA's impact on blood clotting
Acute coronary syndrome remodels the antiplatelet aggregation properties of HDL particle subclasses.
Significant blood clot treatment insights
We explored the effects of eicosapentaenoic acid (EPA), particularly in the context of acute coronary syndrome (ACS), on blood clotting. The study highlighted how different subclasses of high-density lipoprotein (HDL), particularly HDL2 from ACS patients, interact with platelets during clot formation.
It became clear that HDL2 from ACS patients exhibited a stronger ability to inhibit platelet aggregation compared to HDL from healthy individuals. This ability to reduce clot formation is linked to the presence of specific oxidized polyunsaturated fatty acids in the HDL2 particles.
We observed an inverse relationship between several oxidized fatty acids, such as 18-hydroxyeicosapentaenoic acid (18-HEPE) and others, and platelet aggregation. This means that higher levels of these oxidized fats were associated with less platelet activation and clotting, pointing to their potential role in enhancing the antithrombotic properties of HDL2 in ACS patients.
Overall, the findings suggest that EPA and its oxidized metabolites could play a key role in modifying HDL properties, thereby offering some protection against blood clots in individuals with ACS.
It became clear that HDL2 from ACS patients exhibited a stronger ability to inhibit platelet aggregation compared to HDL from healthy individuals. This ability to reduce clot formation is linked to the presence of specific oxidized polyunsaturated fatty acids in the HDL2 particles.
We observed an inverse relationship between several oxidized fatty acids, such as 18-hydroxyeicosapentaenoic acid (18-HEPE) and others, and platelet aggregation. This means that higher levels of these oxidized fats were associated with less platelet activation and clotting, pointing to their potential role in enhancing the antithrombotic properties of HDL2 in ACS patients.
Overall, the findings suggest that EPA and its oxidized metabolites could play a key role in modifying HDL properties, thereby offering some protection against blood clots in individuals with ACS.
Read More
9
Fish oil may reduce clotting risk
Relation of fish oil supplementation to markers of atherothrombotic risk in patients with cardiovascular disease not receiving lipid-lowering therapy.
Study shows potential benefits
We explored the effects of eicosapentaenoic acid (EPA) found in fish oil supplements on the risk of blood clotting in patients with suspected coronary artery disease who weren’t taking lipid-lowering medications. The study included 600 consecutive patients, and we compared those taking fish oil to those who weren’t.
Our findings showed that fish oil supplementation was associated with beneficial changes in several cholesterol levels, particularly lower levels of very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) cholesterol. This aligns with evidence that EPA could play a role in heart health.
Notably, patients who took fish oil demonstrated reduced platelet aggregation and lower levels of urinary thromboxane B2, a marker associated with blood clot formation. This suggests that fish oil could potentially help in lowering atherothrombotic risk, especially for those not on other cholesterol-lowering treatments.
While the results are promising, further studies are warranted to confirm these findings and better understand the independent effects of EPA on blood clotting.
Our findings showed that fish oil supplementation was associated with beneficial changes in several cholesterol levels, particularly lower levels of very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) cholesterol. This aligns with evidence that EPA could play a role in heart health.
Notably, patients who took fish oil demonstrated reduced platelet aggregation and lower levels of urinary thromboxane B2, a marker associated with blood clot formation. This suggests that fish oil could potentially help in lowering atherothrombotic risk, especially for those not on other cholesterol-lowering treatments.
While the results are promising, further studies are warranted to confirm these findings and better understand the independent effects of EPA on blood clotting.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Maintains blood quality
All tests are perfect. I started taking it in the first trimester of pregnancy, and I’m now 27 weeks along. I bought 2-3 cans and continue taking it. I experienced some issues like belching but no nausea. The small capsules are easy to swallow. It's essential to store them in the fridge, as heat can make them smell like fish. Omega is known to help maintain normal blood quality, preventing blood clots. Monthly tests show my platelets and erythrocytes are normal. I highly recommend it!
Read More
8.8
Pregnancy support discussed
Following two miscarriages, my midwife suggested Folate and Baby Aspirin for my next pregnancy. As directed, I got my progesterone checked. The baby aspirin is intended to help prevent any blood clots. I find this routine easy and would recommend it to any expecting mothers, especially those with complications like mine.
Read More
7.5
Improves blood circulation
After pregnancy, I had an issue with a blood clot on my leg, so I bought this for better blood circulation. Interestingly, after taking it, the problem seems to have improved.
7.5
Supports normal indicators
Omega is considered beneficial for thinning blood. Many say it’s particularly useful in the second and third trimesters, but I recommend starting from the first, especially if there is a risk of blood clots. My first pregnancy required clexane, but I managed my second without it, focusing on hydration and this product due to its purification level. I can’t speak to the effects, but my health indicators remain normal.
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